3. Regenerative medicine
Regenerative medicine aims to harness the body’s natural healing and repair mechanisms. It shows great potential for addressing sports and age-related conditions and injuries. Patients can only have a certain number of joint replacements therefore, the significant developments helping to prevent or delay the need for artificial joint replacements can keep people active and in sports. There have been a number of notable innovations in regenerative medicine for treating injuries recently, including acellular dermal matrix scaffolds, platelet-rich plasma therapy and 3D printed scaffolding.
Acellular dermal matrix
One multi-disciplinary approach to improve recovery of sports injuries uses acellular dermal matrix (ADM) scaffolds. ADMs are grafts which act as biological scaffolds, used in soft tissue reconstruction and regenerative medicine, supporting cellular in-growth and revascularisation, which can accelerate healing and improve outcomes. This is especially helpful for tendon and ligament regeneration where these structures are poorly vascularised and they have slowed healing capabilities, making recovery particularly challenging.
Technologies like LifeNet Healths’s MatrACELL® have shown strong biocompatibility for multiple procedures. Arthrex developed an ADM product, ArthroFlex®, that is processed using MatrACELL technology to support rotator cuff repairs, Achilles tendon reconstruction and superior capsular reconstruction. Over 40,000 ArthroFlex grafts have been distributed for use in soft tissue repair procedures and LifeNet Health reports decreased re-tear rates and improved patient reported outcomes after one and two years.
Acellular dermal matrix use is expanding globally and is expected to become more commonplace as regenerative techniques evolve.
Platelet-rich plasma therapy
Platelet-rich plasma (PRP) therapy is advancing in the sports medicine industry. A PRP injection is produced from a patient’s blood using concentrated plasma proteins to promote healing when injected into the injured area. A familiar therapy to athletes, the treatment has been used for common sporting injuries – such as Rafael Nadal for a tendinitis problem.
Recent developments in PRP therapy have focused on optimising its composition, improving delivery methods and expanding its applications in regenerative medicine.
3D-printed scaffolding
Personalised 3D-printed scaffolds are a new generation of implants for tissue engineering and regenerative medicine. Scaffolds support cell growth, providing an artificial extracellular matrix for tissue repair and regeneration and can biodegrade once cells have assumed their physiological and structural roles.
Studies have emphasised 3D-printed scaffolds as a promising technology for enhanced personalised treatment, bone defect repair and bone regeneration in orthopaedics.
The regulatory pathway for personalised implants with be complex, however, recent advancements in the field – such as French MedTech company, TISSIUM, gaining FDA approval for a 3D-printed polymeric solution for the repair of peripheral nerve damage – demonstrate the potential for clinical translation of the technology.